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Gabriel Mateus Bernardo Harrington

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Last updated on 2021-03-27.

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Gabriel Mateus Bernardo Harrington

Research profile

Currently a final-year PhD student at Keele University based in the Spinal Studies group at The Robert Jones and Agnes Hunt Orthopaedic Hospital. Spinal cord injury (SCI) is damage to the spinal cord due to trauma, degeneration or disease that results in a temporary or permanent change to its neurological function, recovery from which is highly variable. SCI can lead to devastating consequences for both the physical and mental health of patients, particularly due to the uncertainty of neurological outcomes in the first two weeks post-injury. The variability of recovery has also stymied development of novel therapies as it makes powering clinical trials extremely difficult.

I endeavour to discover novel biomarkers of SCI outcomes, both to minimise this uncertainty and to expand our understanding of the underlying pathology of neurological recovery. I use a combination of modelling historic patient data and proteomic techniques to this end, and have found evidence of a relationship between markers of liver health and SCI recovery. I am currently validating our prior models with external datasets and seeking to carry out a metabolomics experiment to better elucidate the link between the liver and SCI.

Education

Lancaster University

BSc in Biological Sciences

Lancaster, UK

2016

Dissertation: 5-prime genotyping of Enterovirus 71

Keele University

PhD Student

Oswestry, UK

2017 - present (Expected submission 2021)

Thesis: Biomarker discovery and prognostic modelling in spinal cord injury

Research Experience

Graduate Research Internship

Bionics Institute

Melbourne, Australia

2016 - 2017

  • Began initial work towards building a next-generation cochlea implant
  • Established the viability of using a viral vector for optogenetic modification of mouse cochlea
  • Gained extensive experience in immunohistochemistry, cryosectioning, imaging, research animal handling

Selected Publications

A Preliminary Cohort Study Assessing Routine Blood Analyte Levels and Neurological Outcome after Spinal Cord Injury

Journal of Neurotrauma 2020 Jan 9

N/A

2020

Sharon J. Brown, Gabriel M.B. Harrington, Charlotte H. Hulme, Rachel Morris, Anna Bennett, Wai-Hung Tsang, Aheed Osman, Joy Chowdhury, Naveen Kumar, and Karina T. Wright

Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury

Journal of Neurotrauma 2020 Aug 28

N/A

2020

Gabriel Mateus Bernardo Harrington, Paul Cool, Charlotte Hulme, Aheed Osman, Joy Roy Chowdhury, Naveen Kumar, Srinivasa Budithi, and Karina Wright

Oral and Poster presentations

SCI and the liver

Research day, 2021

The Robert Jones and Agnes Hunt Orthopaedic Hospital, Virtual

2021

N/A

Reproducible Research

CDT Conference, 2019

Manchester University

2019

N/A

Biomarkers for SCI

Postgraduate Conference, 2018

Keele University

2018

N/A

Proteomic analysis of bloods from SCI patients

CDT Joint conference, 2020

Virtual

2020

Gabriel M.B. Harrington, Charlotte H. Hulme, Paul Cool, Karina T. Wright